非酒精性脂肪性肝病相关易感基因及其在发病机制中的作用

Research advances in susceptibility genes and their role in the pathogenesis of nonalcoholic fatty liver disease

非酒精性脂肪性肝病(NAFLD)发病率逐年增高并呈低龄化趋势,严重增加个人及社会经济负担。作为一种遗传-代谢-环境相关疾病,遗传因素在NAFLD发生发展中起着尤为重要的作用。随着全基因组关联研究技术的广泛应用,对NAFLD遗传易感基因的研究不断取得新的进展。总结国内外现有研究成果,以其遗传易感基因多态性为切入点,探讨影响NAFLD的发病因素及内在机制。

Currently the incidence of nonalcoholic fatty liver disease（ NAFLD） is increasing,and the age of onset is getting younger worldwide,resulting in a heavy economic burden for both individuals and the society. Since NAFLD is closely related to heredity,metabolism,and the environment,genetic factors play an important role in the development and progression of NAFLD. With the development and wide application of the techniques from the genome- wide association studies,new research advances have been achieved in the susceptibility genes of NAFLD. This review summarizes the related research findings at home and abroad,and investigates the pathogenic factors for NAFLD and related mechanisms with a focus on the polymorphisms of susceptibility genes.