肝脏免疫炎症在非酒精性脂肪性肝病发生发展中的作用

Role of liver immunological inflammation in development and progression of nonalcoholic fatty liver disease

非酒精性脂肪性肝病(NAFLD)是临床上常见的肝脏疾病之一,其发病机制较为复杂,"二、三次打击"学说仍是目前得到公认的NAFLD的主要发病机制。但近年来,肝脏免疫炎症在NAFLD的发生、发展中逐步得到众多研究者的重视。从肝脏免疫炎症的角度,阐述了肝脏免疫炎症导致NAFLD发生、发展的机制。

Non- alcoholic fatty liver disease（ NAFLD） is a common liver disease in clinical practice and has a complex pathogenesis. At present,the ＂ two- or three- hit＂ theory is still widely acknowledged as the major pathogenesis of NAFLD. However,in recent years,the role of liver immunological inflammation in the development and progression of NAFLD has been taken more and more seriously. This article elaborates on the mechanism of liver immunological inflammation in the development and progression of NAFLD from the perspective of liver immunological inflammation.