依达拉奉联用醒脑静治疗急性一氧化碳中毒疗效分析

Clinical Therapeutic Effect of Edaravone Combined with Xingnaojing on Acute Carbon Monoxide Poisoning

目的探讨在常规治疗基础上加用依达拉奉联合醒脑静治疗急性一氧化碳中毒的临床疗效。方法将150例急性一氧化碳中毒患者随机分为2组,对照组予常规治疗(氧疗+一般治疗),实验组在常规治疗基础上加用依达拉奉联合醒脑静治疗,对比两组间临床治疗效果。结果实验组病情好转时间短于对照组,差异有统计学意义(t=26.5,P=0.0059);实验组有效率(96.0%)高于对照组(77.3%),差异有统计学意义(2=11.31,P=0.001);实验组发生迟发性脑病6例(8.0%)低于对照组16例(21.3%),差异有统计学意义(2=5.33,P=0.02)。结论在常规治疗基础上,依达拉奉联合醒脑静可提高急性一氧化碳中毒患者治疗效果同时改善患者预后的生存质量,值得推广。

Objective To evaluate the therapeutic effect of edaravone combined with Xingnaojing on acute carbon monoxide poisoning on the basis of routine treatment. Methods 150 patients with acute carbon monoxide poisoning were di- vided into 2 groups： the test group was treated with edaravone combined with Xingnaojing and the control group with oxygen therapy and ordinary treatment. The curative effects were compared between them. Results The test group had less recove- ring time, more effective clinical effect （96.0% and 77.3% respectively ） and lower incidence of delayed encephalopathy （ 8.0% and 21.3% ） than the control group, with statistical significance （ t = 26.5, P = 0. 0059 ; X2 = 11.31, P = 0. 001 ; x2 = 5.33, P = 0. 02）. Conclusion Edaravone combined with xingnaojing based on routine treatments can improve the ther- apeutic effect and life quality. It is worthy of promotion.