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血清促甲状腺激素在甲状腺乳头状微小癌的应用价值 被引量:4

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摘要 目的探讨血清促甲状腺激素(TSH)在甲状腺乳头状微小癌(PTMC)的应用价值。方法回顾性分析2011年1月至2014年12月在该院接受结节切除术的1 886例甲状腺结节患者的临床病理资料。根据病理结果和肿瘤大小将患者分为良性甲状腺结节(BTN)组(n=1 182)、PTMC组(肿瘤最大径小于1cm,n=267)及大于1cm分化型甲状腺癌(DTC)组(n=437)。比较3组患者的一般资料、TSH水平及分布,分析TSH水平与临床分期、淋巴结转移、甲状腺外侵袭及结节内钙化之间的关系。结果 PTMC组和DTC组的年龄、病灶最大径均显著低于BTN组,而结节内钙化发生率均显著高于BTN组(P〈0.05)。PTMC组的病灶最大径、淋巴结转移率和甲状腺外侵袭率均显著低于DTC组(P〈0.05)。DTC组的TSH水平显著高于BTN组(P〈0.05),PTMC组和另外两组的TSH水平比较,差异无统计学意义(P〉0.05)。随着TSH水平的增高,BTN的患病率逐渐降低,DTC的患病率逐渐升高(P〈0.05),而各TSH水平的PTMC的患病率比较,差异无统计学意义(P〉0.05)。Ⅲ~Ⅳ期、有淋巴结转移、无甲状腺外侵袭、无结节内钙化患者的TSH水平明显高于Ⅰ~Ⅱ期、无淋巴结转移、有甲状腺外侵袭、有结节内钙化患者,差异有统计学意义(P〈0.05)。结论 TSH水平与DTC的发生、发展和结节内钙化密切相关,可作为预测DTC病灶恶性程度的参考指标。
出处 《重庆医学》 CAS 北大核心 2016年第10期1399-1401,共3页 Chongqing medicine
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