吉西他滨联合XELOX化疗对结直肠癌患者术后的疗效

Postoperative curative effects of gemcitabine combined with XELOX chemotherapy on patients with colorectal cancer

目的探讨吉西他滨联合XELOX化疗方案对结直肠癌术后患者的临床疗效及生活质量的影响。方法将80例结直肠癌术后患者随机分成分两组,每组40例。观察组采用吉西他滨联合XELOX化疗方案治疗,对照组单用XELOX化疗方案治疗,14 d为1个疗程,连续治疗8个周期。观察两组临床疗效及患者治疗后生活质量改变情况,评价两种治疗方案的临床治疗价值。结果观察组缓解率和疾病控制率均明显优于对照组(P<0.05);治疗后观察组在"腹胀"、"脱发"、"肛门排气"、"总体生活质量"、"角色功能"、"情感功能"、"认知功能"、"社交功能"、"疲劳"、"恶心和呕吐"、"失眠"、"经济困难"等生活质量方面评分均优于对照组(P<0.05)。结论吉西他滨联合XELOX化疗方案对结直肠癌术后患者的临床疗效肯定,不良反应少,可提高患者的生活质量,值得临床推广应用。

Objective To investigate the postoperative clinical curative effects of gemcitabine combined with XELOX chemotherapy on patients with colorectal cancer and the influence on their quality of life. Methods 80 patients receiving the operation on colorectal cancer were randomly and averagely divided into two groups. Observation group was given the treatment with gemcitabine combined with XELOX chemotherapy, while control group was given XELOX chemotherapy. Fourteen days were a course of treatment, and the treatment course was 8 weeks. Observation was made in the clinical curative effects and patients＇ life quality after the treatment between the two groups. Results The remission rates and the disease control rates of the observation group were superior to those of the control group（P〈0.05）. After the treatment, the scores of the life quality in the aspects of abdominal distension, hair loss, the anus exhaust, the overall quality of life, role function, emotional function, cognitive function, social function,fatigue, nausea and vomiting, insomnia, and economic difficulties in the observation group were better than those in the control group（P〈0.05）. Conclusion The combination of gemcitabine and XELOX chemotherapy has certain postoperative clinical curative effects on patients with colorectal cancer and has less adverse reactions, which can improve the patients＇ life quality and is worthy of clinical application.