DWI与动脉自旋标记成像在胶质瘤术前诊断中的应用价值

Application of diffusion-weighted imaging and arterial spin labeling in evaluating cerebral gliomas

目的 :探讨DWI及动脉自旋标记法(arterial spin labeling,ASL)在胶质瘤术前分级中的应用价值。方法:选取28例经手术病理证实的脑肿瘤患者,其中高级别胶质瘤(high grade glioma,HGG)18例,低级别胶质瘤(low grade glioma,LGG)10例。所有患者均行DWI及ASL扫描,比较不同级别胶质瘤ADC值及脑血流量(CBF)值的差异。结果:HGG肿瘤实质区CBF值大于LGG;HGG肿瘤实质区ADC值小于LGG;且不同级别胶质瘤ADC值与CBF值有显著相关性(r=-0.759,P=0.002)。结论 :DWI及ASL可于术前安全无创地评估脑胶质瘤级别,有助于临床制订治疗方案。

Objective：To explore the usefulness of diffusion-weighted imaging（DWI） and arterial spin labeling（ASL） in evaluating brain tumors. Methods：Twenty-eight patients with pathologically determined brain tumors were enrolled in this study. The brain tumor included high grade glioma（n=18） and low grade glioma（n=10）. Both DWI and ASL were performed in all the 28 patients,and the cerebral blood flow （CBF）,apparent diffusion coefficient （ADC） were quantitatively determined. Results：The CBF of HGG parenehyma area was greater than the LGG; while the ADC of HGG parenehyma area was lower than LGG. And there was a signification correlation（r=-0.759,P=0.002） existed between CBF and ADC. Conclusion：Both DWI and ASL can be used for non-invasively evaluated the grade of glioma in preoperative diagnosis,then helps making an appropriate plan before operation.