止咳平喘方辅助治疗支气管哮喘疗效观察及对肺功能、细胞因子的影响

Effect of Zhike Pingchuan Fang on the pulmonary function and cytokines in treating children with bronchial asthma

目的观察止咳平喘方治疗支气管哮喘患儿的效果及对肺功能、细胞因子的影响。方法 185例支气管哮喘患儿随机分为治疗组95例和对照组90例,对照组给予西医常规治疗,治疗组在对照组治疗方法的基础上给予止咳平喘方。治疗28 d后观察2组患儿的临床疗效以及肺功能[第1秒最大呼气量(FEV1)、峰流速值(PEF)、第1秒最大呼气量占用力肺活量的比值(FEV1/FVC)]、辅助性T细胞亚群(Th1/Th2)型细胞因子[γ-干扰素(IFN-γ)、白细胞介素(IL)-4、IL-6、IL-8]的变化。结果治疗组总有效率为97.89%,对照组为93.33%,2组比较差异有统计意义(P<0.05);治疗后2组患儿肺功能指标FEV1,PEF,FEV1/FVC及细胞因子IFN-γ,IL-4,IL-6,IL-8均显著改善,与同组治疗前比较差异有统计意义(P<0.05),且治疗组作用显著优于对照组(P<0.05)。结论止咳平喘方可提高支气管哮喘患儿的临床疗效,有助于改善肺功能、纠正Th1/Th2型细胞因子水平,值得临床推广。

Objective To observe the curative effect of Zhike Pingchuan Fang in the treatment of children with bronchial asthma and its effect on pulmonary function and cytokines. Methods 185 cases of bronchial asthmatic children were divided into treatment group（ 95 cases） and control group（ 90 cases） randomly. The control group was treated with conventional Western medicine. The treatment group was additionally given Zhike Pingchuan Fang.After 28 days treatment,the clinical effect,pulmonary function（ forced expiratory volume in one second,FEV1）,peak expiratory flow（ PEF）,FEV1/ FVC,IFN-γ,IL-4,IL-6,IL-8 were analyzed. Results The total efficiency was97. 89% in the treatment group and 93. 33% in the control group（ P〈0. 05）,there was statistical significance. After the treatment,FEV1,PEF,FEV1/ FVC and cytokine IFN-γ,IL-4,IL-6 and IL-8 were significantly improved,compared in the same group before treatment（ P〈0. 05）,and the treatment group was better improved than the control group after treatment（ P〈0. 05）. Conclusion Zhike Pingchuan Fang can improve the clinical curative effect in treating with bronchial asthma,help to improve pulmonary function,correct Th1 / Th2 cytokine levels,worthy of clinical application.