淋巴瘤患者血清bFGF、p53水平变化在临床中的研究

THE CLINICAL CHANGES OF BFGF AND P53 IN SERUM OF PATIENTS WITH LYMPHOMA

目的探讨bFGF、p53在非霍奇金淋巴瘤(NHL)病情评估、治疗、预后等方面的作用。方法应用酶联免疫法(ELISA)法检测30例NHL患者治疗前后血清中bFGF、p53的含量,用25例健康人的血清作对照。结果 NHL患者血清bFGF、p53的含量明显高于正常人的水平(P<0.01),伴骨髓浸润的NHL患者血清bFGF、p53含量明显高于未有骨髓浸润患者,完全缓解者血清bFGF、p53含量比治疗前明显降低,在NHL的不同分期,血清bFGF、p53的含量不同,差异有统计学意义(P<0.05)。结论血清bFGF、p53在NHL病情评估、治疗方案的选择、预后等方面有重要的临床指导意义。

Objective To explore the roles of basic fibroblast growth factor （bFGF） and p53 in the as-sessment, treatment and prognosis of non-Hodgkin＇s lymphoma （NHL）. Methods ELISA method was used to detect the content changes of serum sbFGF and p53 in 30 cases of NHL before and after treatment. 25 cases of healthy people were chosen as controls. Results The content of NHL serum bFGF and p53 was obviously higher than that of normal level （ P 〈 0.01）. The content of NHL serum bFGF and p53 in patients with NHL and bone marrow infiltration was significantly higher than that of patients with NHL but without bone marrow infiltration（ P 〈 0.05）. The content of NHL serum bFGF and p53 in patients of complete remission was much lower that than before treatment （ P 〈 0.05）. Conclusion The content of NHL serum bFGF and p53 in patients with NHL play an important role in in the assessment, treatment and prognosis of NHL.