纳米粒子在肿瘤成像及治疗中的研究进展

Progress of Nanoparticles in Tumor Image and Treatment

纳米粒子（20~400 nm）颗粒小,可通过血管的渗透增强和滞留效果而积累在肿瘤细胞中,避免被肾脏所清除,从而使其在血管中有更长的血液循环时间;纳米粒子比表面积大,可以携带大量的化疗药物用于药物的传递;纳米粒子表面经过改造后可以结合不同的靶向基团,并利用共价键结合到细胞表面受体,从而可将药物运输到特定的部位。近年来,越来越多的科研工作者致力于研究纳米颗粒与一些生物分子之间的关系,以此来开发更有效和特异性的抗癌药物。引用了近10年的参考文献,主要介绍了纳米粒子在肿瘤成像及治疗中的应用。

The size of nanoparticles（ 20 ~ 400 nm） makes it can accumulate in the tumors by the effect of enhancing permeability and retention effect. It can avoid renal filtration and has a long blood circulation times. In the same time,the surface of nanoparticles is big enough for drug delivery,it can conjugate to different chains after surface modification and conjugate to the surface of tumor by the receptors. Thus,it can transfer the drug to the especial position. In recent years,more and more scientists devote to research the relation between nanoparticles and biomaterials in order to develop more efficient and specificity anti-cancer drug. In this work,an overview of the use of nanoparticles in tumors diagnose and treatment is provided.