稳定同位素^(15)N标记2-甲基-5-硝基咪唑的合成与表征

Synthesis and Characterization of Stable Isotope ^(15)N Labeled 2-Methyl-5-nitroimidazole

以15NH3和H15NO3作为同位素原料,经两步反应得到目标产物15N标记2-甲基-5-硝基咪唑。收率以15NH3计,为58%,经液相色谱(HPLC)、质谱(MS)、气体同位素质谱计(MAT-271)等对其纯度和丰度进行表征,纯度>99.5%,丰度>99%,可作为制备15N标记硝基咪唑类药物内标检测试剂的合成前体。

An efficient synthesis was established to prepare the stable isotope15 N labeled 2-methyl-5-nitroimidazole with15NH3 and H15NO3as the raw material. The total yield was 58% based on15NH3 consumed. The target compound was confirmed by HPLC,MS and MAT-271. The chemical purity is 99. 5% and deuterium isotopic enrichment is 99. 0 atom%15N. The compound could be used as the synthetic precursor for prepare15 N labeled nitroimidazole.