柴芩承气汤对重症急性胰腺炎大鼠内毒素、白细胞介素-6的影响

Effects of Chaiqin Chengqi Decoction on Endotoxin and Interleukin-6 in Rats with Severe Acute Pancreatitis

目的:研究柴芩承气汤对重症急性胰腺炎大鼠内毒素、白细胞介素-6的影响。方法:选取36只SD大鼠,按随机数字表法分为3组,观察各组动物血浆、肺组织、回肠组织病理的变化,分别测定内毒素、白细胞介素-6在不同病理以及不同时间段治疗的浓度变化。结果:治疗后,SAP+柴芩承气汤治疗组大鼠内毒素浓度的变化(0.077±0.013)Eu/m L显著低于模型组的浓度(3.31±0.698)Eu/m L,差异有统计学意义。治疗后,SAP+柴芩承气汤治疗组大鼠白细胞介素-6浓度的变化(45.17±6.13)pg/m L显著低于模型组的浓度(87.31±5.98)pg/m L,差异有统计学意义。结论:柴芩承气汤对重症急性胰腺炎大鼠内毒素、白细胞介素-6具有一定的影响,值得广泛推广使用。

Objective： To study the Chaiqing Chengqi decoction influence toxin and interleukin-6 on rats with severe acute pancrentitis. Methods： 36 SD rats, according to a random number table divided into three groups. Observed in plasma, lung tissue of animals in each group. Endotoxin, interleukin-6 concentrations were measured in different pathological changes and the different time periods of treatment. Results： After treatment, SAP ＋ changes in toxin concentration in Chaiqin-Chengqi Treated rats （0. 077 ＋ 0. 013） Eu / mL concentration was significantly lower than the model group （3.31 ＋ 0. 698） Eu/ mL, the difference has statistically significance. After treatment, SAP ＋ changes in interleukin-6 concentrations Chaiqingchengqi Treated rats （45. 17 ＋ 6.13） pg/ mL concentration was significantly lower than the model group （87.31 ＋ 5.98） pg / mL, the difference has statistically significance. Conclusion： Chaigin Chengqi Decoction decoction on rats with severe acute toxin within the interleukin-6 has a certain influence, which worth widely used.