注射用依那西普联合骨痹汤治疗幼年脊柱关节病的临床观察

Clinical effects of Etanercept for injection combined with Gubi decoction on the treatment of juvenile-onset spondyloarthropathies

目的观察注射用依那西普联合骨痹汤治疗幼年脊柱关节病(JSp A)的临床疗效。方法将77例JSp A患者随机分为2组,治疗组40例应用注射用依那西普联合骨痹汤治疗,对照组37例单纯应用柳氮磺吡啶肠溶片治疗。2组均治疗12周,观察2组治疗前、治疗2周后及治疗12周后红细胞沉降率(ESR)、C反应蛋白(CRP)、血小板计数(PLT)及视觉模拟评分(VAS)变化,比较2组疗效。结果 2组治疗过程中ESR、CRP、PLT及VAS评分均逐步降低,治疗2周后比较差异无统计学意义(P>0.05),但治疗12周后,2组均较本组治疗前降低(P<0.05),且治疗组各项观察指标较对照组降低更明显(P<0.05)。治疗组缓解率55.0%、总有效率97.5%,对照组缓解率27.0%、总有效率81.1%,2组缓解率、总有效率比较差异均有统计学意义(P<0.05),治疗组疗效优于对照组。结论注射用依那西普联合骨痹汤治疗JSp A,疗效显著,安全性好。

Objective To observe the effects of Etanercept for injection combined with Gubi decoction on the treatment of juvenile-onset spondyloarthropathies（ JSp A）.Methods 77 subjects with JSp A were randomly divided into two groups.40 subjects in treatment group were treated by Etanercept for Injection combined with Gubi decoction.37 subjects in control group were treated by simple sulfasalazine enteric-coated tablets.The course was 12 weeks in two groups.The erythrocyte sedimentation rate（ ESR）,C-reactive protein（ CRP）,blood platelet count（ PLT） and visual analogue scale/score（ VAS） before,two weeks and twelve weeks after treatment were observed intwo groups,and the curative effects were compared between two groups.Results The above-mentioned indexes were gradually decreased during treatment in two groups,andthere were no statistical differences in two weeks after treatment between two groups（ P〈0.05）.Above-mentioned indexes twelve weeks after treatment were decreased in two groups（ P〈0.05）,and the decrease in treatment group was lower than that in control group（ P〈0.05）.The remission rate and total effective rate in treatment group（ 55.0%,97.5%） were superior to that in control group（ 27.0%,81.1%,P〈0.05）.Conclusion Etanercept for injection combined with Gubi decoction has significant and stable efficacy on the treatment of JSp A,with high safety.