摘要
目的探讨CXCR7在胶质瘤中的表达及其与预后的相关性。方法收集89例不同病理级别胶质瘤,应用免疫组化方法检测CXCR7在胶质瘤中的表达。结果 23例患者的CXCR7呈强阳性染色(),24例呈中度阳性染色(),17例呈弱阳性染色(+),25例呈阴性染色(-),且CXCR7在胶质瘤组织中的表达与胶质瘤的病理级别呈正相关。较强的CXCR7染色患者的存活时间较短。结论 CXCR7可以做为胶质瘤病理级别分类及预后判断的生物学标记物。
Objective To analyze the expression and clinical significance of CXCR7 in human glioma tumor tissue. Methods 89 cases of glioma were selected and the expressions of CXCR7 were detected by immunohistochemistry methods in glioma tissue. Results Among all the 89 cases of glioma specimens investigated,there were 23 cases strong positive staining（ ） of CXCR7,24 cases moderate positive staining（ ）,17 cases weak positive staining（ ＋） and 25 cases negative staining（-） respectively. The expression level of CXCR7 was positively correlated with glioma malignancy. Conclusions The expression of CXCR7 is closely correlated to development and prognosis of human glioma.
出处
《中国老年学杂志》
CAS
CSCD
北大核心
2016年第7期1639-1641,共3页
Chinese Journal of Gerontology
基金
国家自然科学基金资助项目(No.81372484)
