黑色素的合成与美白产品的研究进展

A review of the studies on melanin synthesis and whitening products

随着环境污染对大气臭氧层的不断破坏,越来越多的紫外线照射到地球表面,加重了人类皮肤色素沉积异常.本文将介绍黑色素的合成过程,并综述黑色素合成过程中的关键限速酶——酪氨酸酶(TYR)的调控方式和相关信号通路的最新研究进展,还介绍了影响黑色素合成的重要因素,为黑色素抑制剂的研发提供理论依据.此外,本文还综述了目前市场上常见的几类美白产品及其特点,旨在让人们重视肌肤色素沉着问题,并关注对皮肤黑色素产生进行科学护理.

Due to environmental pollution and the increasing size of the ozone hole, more UV rays penetrate the atmosphere and reach the ground, which leads to skin pigmentation abnormali- ties. In this article, we reviewed the latest studies on melanin synthesis, mainly focusing on the regulation and related signal pathways with regard to tyrosinase, a vital rate- limiting enzyme involved in this process. Several critical factors affecting melanin synthesis were also presented, providing theoretical basis for screening melanin inhibitors. In addition, several new popular commercial whitening products and their property were discussed. All these information is benificial to draw the public＇s attention to skin pigmentation disorder as well as proper care.