运脾颗粒对幼龄厌食模型大鼠消化功能的影响

Influence of YunPi Granules on Digestive Function of Juvenile Rats with Anorexia

目的:探讨运脾颗粒对幼龄厌食模型大鼠消化功能的影响。方法:将60只SD幼龄大鼠随机分为正常对照组、模型对照组、阳性对照组(儿宝颗粒,1.75 g/kg)、运脾颗粒高剂量组(4.20 g/kg)、运脾颗粒中剂量组(2.10 g/kg)、运脾颗粒低剂量组(1.05 g/kg),每组10只,模型建立后灌胃给药。结果:与模型对照组比较,运脾颗粒不同剂量组体质量均有不同程度的增加(P<0.05);与模型对照组比较,运脾颗粒不同剂量组24小时摄食量均有不同程度的增加(P<0.05);与模型组对照组比较,运脾颗粒高剂量组大鼠胃排空率和肠推进率明显增大(P<0.05);与模型对照组比较,运脾颗粒各剂量组大鼠脾脏指数均明显减小(P<0.05)。结论:运脾颗粒对幼龄厌食模型大鼠一定的调节作用。

Objective： To explore the influence of YunPi granules on digestive function of juvenile rats with anorexia. Methods： Sixty SD rats were randomized into normal control group, model control group, positive control group（Er Bao granules, 1.75 g/kg）, high（4.20 g/kg）, moderate（2.10 g/kg） and low（1.05 g/kg） doses groups of YunPi granules, ten rats each group, the models accepted intragastric administration after the models were established. Results： Compared with model control group, body weights of rats in different doses groups of YunPi granules increased in different degrees（P〈0.05）; compared with the model control group, 24 hours food intake of the rats in different doses groups of YunPi granules increased to different extents（P〈0.05）; compared with the model control group, gastric emptying rate and intestinal propulsion rate increased remarkably in high dose group of YunPi granules（P〈0.05）; compared with the model control group, spleen indexes of the rats in different doses groups of YunPi granules decreased notably（P〈0.05）. Conclusion： YunPi granules could regulate juvenile rats with anorexia to a certain degree.