我国药物毒理学基础研究发展回顾:基于2001-2015年国家自然科学基金“药物毒理”方向资助项目分析

Fundamental research in drug toxicology of China:analysis based on ″drug toxicology″ projects funded by National Natural Science Foundation of China between 2001 and 2015:a review

药物毒理学是研究药物毒性的作用机制,并对药物进行全面系统的安全性评价的一门学科,在指导临床合理用药,降低药物不良反应及减少因药物毒性而导致的新药开发失败等方面起到了至关重要的作用。本文就国家自然科学基金(NSFC)2001-2015年期间"药物毒理"方向资助项目的数量、经费、资助率、类别、依托单位分布和NSFC指南变化等基本情况进行了总结,归纳"药物毒理"研究方向资助项目的主要研究内容、项目研究思路和主题,以及分析总结NSFC资助的特点及存在的问题,展望未来发展趋势,以期为药物毒理学工作者提供参考。

Drug toxicology,as a discipline which studies drug toxicity mechanisms and evaluates comprehensive drug safety is of crucial importance for guiding sensible clinical drug use,reducing adverse drug reactions and reducing failures of new drug development caused by toxicity. This article summarizes the basic situation of Natural Science Foundation of China（NSFC）funded projects in drug toxicology between 2001 and 2015,involving the amount of approved grants,funding rate,funding category and supported faculty,and the change of NSFC guidelines. Research topics,ideas and contents of NSFC funded projects are generalized and characteristics,problems and future trends are also analyzed to provide reference for research on drug toxicology.