前S1抗原在住院精神病乙型肝炎患者临床检验中的应用价值

Application value of pre-S1 antigens in the clinical laboratory of hospitalized mental patients with hepatitis B

目的探讨前S1抗原在住院精神病乙型肝炎患者临床检验中的应用价值。方法对383例住院精神病乙型肝炎患者的血清样本，采用酶联免疫吸附试验法进行乙型肝炎病毒血清标志物与前S1抗原联合检测，并对检测结果进行分析。结果本组表面抗原阳性的模式中，乙型肝炎病毒前S1抗原的阳性率为56．1％，大三阳者前S1抗原阳性率为88．4％，小三阳者前S1抗原阳性率为55．0％。结论前S1抗原较乙型肝炎病毒血清标志物更为敏感，可以作为一种新的乙型肝炎病毒血清标志物和监测指标。

Objective To explore the application value of pre-S1 antigens in the clinical laboratory of hospitalized mental patients with hepatitis B. Methods Hepatitis b virus （HBV） and pre-S1 antigens combined detections were carried out using enzyme linked immunosorbent assay （ELISA） for serum samples of 383 hospitalized mental patients with hepatitis B and detection results ana- lyzed. Results In positive surface antigen mode positive rate of HBV pre-S1 antigens was 56.1%, that was 88.4% of patients with HBsAb, HBeAg and HBcAb positive samples, and 55.0% of HBeAb positive. Conclusion Pre-S1 antigens are more sensitive compared with HBV serum markers and could be used as a new HBV serum marker and monitoring index.