肺癌化疗患者PICC相关上肢深静脉血栓的危险因素分析

Analysis of risk factors for PICC-related venous thrombosis in lung cancer patients

目的探讨初诊化疗6个周期的肺癌患者PICC相关性深静脉血栓发生的危险因素。方法回顾性分析291例PICC置管肺癌患者的资料，单因素分析肺癌患者的一般资料和置管资料，将单因素有统计学意义的资料纳入多因素Logistic回归模型进行分析。结果肺癌患者PICC相关性深静脉血栓发生15例，发生率为5．15％。多因素Logistic回归分析结果发现Ⅲ-Ⅳ期、置管前D-二聚体〉0．5mg／ml、腺癌是肺癌合并PICC相关性血栓的危险因素，OR值分别为8．675、9．761、10．262。结论对于肺癌化疗6个周期的患者，及时采取行之有效的预防措施，可减少PICC相关性深静脉血栓的发生。

Objective To understand the relevant risk factors in lung cancer patients with chemotherapy complicated with PICC-related venous thrombosis. Methods We retrospectively analyzed 291 cases of lung cancer patients with general information and PICC catheter information. We analyzed the relationship between the general information,the PICC insertion information and the PICC-related thrombosis. Results A total of 15 patients developed PICC-related venous thrombosis in 291 cases,and the incidence was 5.15%. Single factor analysis showed that the difference between the PICC-related venous thrombosis and the pathological type of lung cancer, tumor staging,D-direct before insertion,puncture ways,puncture sites,puncture veins had statistical significance（All P〈0.05）;Multiple factor logistic regression analysis showed that the tumor pathological type,tumor stage,D-dimer before insertion were risk factors of PICC-related venous thrombosis in lung cancer patients. Conclusion For lung cancer patients,taking timely and effective preventive measures can reduce the occurrence of PICC-related venous thrombosis. [Key words] Lung Neoplasms; Venous Thrombosis; Root Cause Analysis