E-钙黏蛋白异常表达与鼻咽癌临床病理关系的Meta分析

Relationship between aberrant expression of E-cadherin and clinicopathological characteristics of nasopharyngeal carcinoma:a Meta-analysis

目的：探讨E-钙黏蛋白（E-cadherin）在鼻咽癌组织中的异常表达与临床病理的关系,为临床提供参考。方法：计算机检索Cochrane Library、Pubmed、EMbase数据库以及中国生物医学文献数据库、中国学术期刊全文数据库中有关E-cadherin与鼻咽癌研究的文献,采用STATA 11.0软件包进行分析。异常表达、分化程度、T分期、淋巴结转移状况及临床分期采用优势比（OR）及95%可信区间（CI）作为效应量进行分析。结果：入选16篇文献共包括1 040例鼻咽癌患者,结果显示E-cadherin在鼻咽癌组织中的异常表达较正常对照组明显增加（OR=0.096,95%CI：0.036-0.252,P=0.000）;E-cadherin异常表达与分化程度、淋巴结转移及临床分期明显相关（OR=0.232,95%CI：0.061-0.884,P=0.032;OR=0.324,95%CI：0.198-0.531,P=0.000;OR=0.441,95%CI：0.232-0.835,P=0.012）。E-cadherin异常表达者肿瘤分化程度低,更易出现淋巴结转移,肿瘤分期偏晚。结论：E-cadherin在鼻咽癌组织中存在异常表达。E-cadherin可以作为鼻咽癌患者分化程度、淋巴结转移及临床分期的判断指标,值得进一步深入研究。

OBJECTIVE： To understand the relationship between aberrant expression of E-cadherin in nasopharyngeal carcinoma（NPC） and clinicopathological features of NPC patients for clinical applications. METHODS： International publications about E-cadherin and NPC were selected from the Cochrane Library, Pubmed,EMbase database,and Chinese publications were from CBM,CNKI. All analyses were performed by software STATA 11.0. Abnormal expression,degree of differentiation,T stage,lymph node metastasis,and clinical stage were analyzed using pooled odds ratio（OR） with 95% confidence interval（CI）. RESULTS：A total of 16 studies including 1040 patients were enrolled in the Meta-analysis. It was shown that expression of E-cadherin was significantly increased in NPC compared to that in normal tissues（OR=0.096,95% CI：0.036-0.252,P=0.000）. In addition,the aberrant expression of E-cadherin was significantly associated with the degree of differentiation,lymph node metastasis and clinical stages（OR= 0.232,95% CI：0.061-0.884,P=0.032;OR=0.324,95% CI：0.198-0.53,P=0.000;OR= 0.441,95% CI： 0.232-0.835,P=0.012）. CONCLUSION：NPC often showed aberrant expression of E-cadherin. In addition,patients with the aberrant expression were prone to having tumors at lower differentiation,with lymph node metastasis and at late clinical stage. E-cadherin may be an indicator for differentiation,lymph node metastasis and clinical stage.