中国人群中XRCC1Arg194Trp位点多态性和结直肠癌易感性关系的Meta分析

Association between polymorphisms of XRCC1Arg194Trp and susceptibility to colorectal cancer in Chinese:a Meta-analysis

目的：探讨中国人群中X射线交叉互补修复基因1（XRCC1）的194位点（Arg194Trp）多态性与结直肠癌（CRC）易感性的关系。方法：检索万方数据知识服务平台、中国生物医学数据库（CBM）、中国知网（CNKI）、维普数据库（VIP）、Pub Med、EBASE等数据库,获取有关XRCC1 Arg194Trp位点多态性与结直肠癌易感性关系的文献,应用Meta分析软件Review Manager 5.1对最终纳入的文献进行综合定量评价,并进行异质性分析、敏感性分析、发表偏倚分析及亚组分析。结果：经过筛选最终纳入10个研究。Meta分析结果示纯合子模型的合并OR=1.40,95%CI（1.13-1.73）,P=0.002;显性模型的合并OR=1.22,95%CI（1.01-1.47）,P=0.04;隐性模型的合并OR=1.30,95%CI（1.06-1.60）,P=0.01;杂合子模型的合并OR=1.19,95%CI（1.00-1.42）,P=0.05。在亚组分析中,病例组吸烟者和对照组吸烟者的OR=1.04,95%CI（0.84-1.29）,P=0.72;病例组饮酒者和对照组饮酒者的OR=1.08,95%CI（0.81-1.44）,P=0.60。结论：XRCC1 Arg194Trp位点多态性和结直肠癌易感性有关系,在纯合子模型、显性模型及隐性模型中携带194Trp基因型个体发生结直肠癌的危险性会增加,吸烟、饮酒与结直肠癌发病率无明显关联。

OBJECTIVE： To investigate whether the polymorphisms of Arg194 Trp on X-ray repair crosscomplementing group 1（XRCC1） would influence susceptibility to colorectal cancer among Chinese. METHODS：We collected publications which discussed association between polymorphisms of XRCC1 Arg194 Trp and susceptibility to colorectal cancer in Chinese people by searching the databases（wanfangdata,CBM,CNKI, VIP,Pub Med,EBASE）. The pooled ORs with their 95%CI were calculated by using Review Manager 5.1 software. We also conducted the heterogeneity and sensitivity,publication bias and subgroup analyses. RESULTS：After filtering,10 studies were included on the selection criteria. The result of this Meta-analysis demonstrates：homozygous model,OR=1.40,95%CI（1.13-1.73）,P=0.002;dominant model,OR=1.22,95%CI（1.01-1.47）,P=0.04;recessive model,OR=1.30,95%CI（1.06-1.60）,P=0.01;heterozygous model,OR=1.19,95%CI（1.00-1.42）,P=0.05. In the subgroup analysis,the value of OR between smokers in case group and smokers in control group is 1.04,95%CI（0.84-1.29）,P=0.72;the value of OR between drinkers in case group and drinkers in control group is 1.08,95%CI（0.81-1.44）,P=0.60. CONCLUSION： The polymorphisms of Arg194 Trp on XRCC1 contributed to susceptibility of colorectal cancer. Those who carried the 194 Trp genotype had increased risk of colorectal cancer in the dominant,homozygous and recessive models. Smoking and drinking had no significant correlation with the incidence of colorectal cancer.