叶酸补充量与血脂及血清肌酐水平相关性的研究

Relationship between Folic Acid Supplementation and Level of Blood Lipids and Serum Creatinine

目的:探讨补充不同剂量叶酸与血脂及血清肌酐的关系。方法:对就诊于某院神经内科门诊或住院患者具有动脉粥样硬化高危因素者随机分为两组,A组口服叶酸0.4mg/d和B组口服叶酸5mg/d共3个月,比较服用前后血叶酸、同型半胱氨酸、血脂及血清肌酐变化。结果:A组叶酸补充后总胆固醇及低密度胆固醇下降、apoA1升高且具有统计学意义;A组和B组叶酸补充后血清肌酐均下降且有统计学意义。结论:低剂量的叶酸补充对降低血总胆固醇及低密度胆固醇、升高HDL及apoA1更有益;补充叶酸可能对降低血清肌酐有益。

Objective:To study the relationship between folic acid supplementation and blood lipids and serum creatinine.Methods:The enrolled individuals were divided into two groups:A group took FA at a low dose of 0.4mg/d and B group taking FA at a high dose of 5mg/d for 3months.Compare change of folic acid,Hcy,blood lipids and creatinine before and after the administration.Results:Mean concentrations of total cholesterol and LDL reduced and apoA1 concentration increased in group A after FA supplementation.Mean level of creatinine decreased after FA supplementation in both groups,and these differences were statistically significant.Conclusion:Low dose FA supplementation has a beneficial effect on reducing total cholesterol and LDL and increasing HDL and apoA1.FA supplementation may have a beneficial effect on reducing serum creatinine.