金属-有机骨架用于各类药物的控释载体

Metal-organic frameworks used as delivery vehicles for therapeutic agents

新型控释药物直接作用于靶细胞,提高药理效率、减小毒副作用,已成为一种极具潜力的药疗方法。与一般药物控释载体相比,金属-有机骨架材料(metal-organic frameworks,MOFs)的优势明显,将其颗粒尺寸降至纳米级后性能更为优异,能同时兼顾药物负载量、目标靶向性、表面特性改善和生物相容性等特性。目前,已有较多类药物吸附在MOFs上的研究报道,主要包括抗癌药物、抗病毒药物及消炎药物。介绍了MOFs的毒性及其发展过程,详细阐述了MOFs对于各类药物的吸附-释放情况,并对此领域的研究和发展进行总结和展望,以期对MOFs作为药物控释载体的应用有比较全面的认识。

Drug sustained delivery emerging as a class of therapeutics for the particular subsets of cells or tissues,that can show enhanced efficacy,while simultaneously reducing side effects,owing to properties such as less dose,more targeted localization in tumours and active cellular uptake.Metal-organic frameworks(MOFs)possess several potential advantages over conventional medicines,notabl they scaled down to nanometer sizes(NMOFs).MOFs have been used as promising drug carriers in biomedical applications due to the high drug loading capacity,intrinsic biodegradability,and versatile functionality.The bulk MOFs can absorb and release large amounts of therapeutic including anticancer and antiviral drugs and anti-inflammatory drugs.In this review,we outline the recent progress of using MOFs as delivery vehicles for therapeutic agents,demonstrate the continuous development and implementation in biomedical toxicology.Although signicant progress has been made in utilizing MOFs for drug delivery,further improvements must still occur before they can be considered for clinical therapeutics.