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Effect of Autophagy Over Liver Diseases

Effect of Autophagy Over Liver Diseases
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摘要 In recent years,increasingly evidences show that autophagy plays an important role in the pathogenesis and development of liver diseases,and the relationship between them has increasingly become a focus of concern.Autophagy refers to the process through which the impaired organelles,misfolded protein,and intruding microorganisms is degraded by lysosomcs to maintain stability inside cells.This article states the effect of autophagy on liver diseases(hepatic fibrosis,fattv liver,viral hepatitis,and liver cancer),which aims to provide a new direction for the treatment of liver diseases. In recent years, increasingly evidences show that autophagy plays an important role in the pathogenesis and development of liver diseases, and the relationship between them has increasingly become a focus of concern. Autophagy refers to the process through which the impaired organelles, misfolded protein, and intruding microorganisms is degraded by lysosomes to maintain stability inside cells. This article states the effect of autophagy on liver diseases (hepatic fibrosis, fatty liver, viral hepatitis, and liver cancer), which aims to provide a new direction for the treatment of liver diseases.
出处 《Chinese Medical Sciences Journal》 CAS CSCD 2016年第1期65-68,共4页 中国医学科学杂志(英文版)
基金 Supported by the National Natural Science Foundation of China(81373465)
关键词 肝脏疾病 自噬作用 微生物降解 病毒性肝炎 发病机制 错误折叠 肝纤维化 细胞器 autophagy hepatic fibrosis fatty liver viral hepatitis liver cancer
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  • 1Damme M, Suntio T, Saftig P, et al. Autophagy in neuronalcells: general principles and physiological and pathologicalfunctions. Acta Neuropathol 2015; 129:337-62.
  • 2Jewell JL, Russell RC, Guan KL. Amino acid signallingupstream of mTOR. Nat Rev Mol Cell Biol 2013; 14:133-9.
  • 3Ni HM, Bockus A, Wozniak AL, et al. Dissecting the dynamicturnover of GFP-LC3 in the autolysosome. Autophagy2011; 7:188-204.
  • 4Cai Z, Yan LJ. Rapamycin, autophagy, and Alzheimer'sdisease. J Biochem Pharmacol Res 2013; 1:84-90.
  • 5Chen Y, Azad MB, Gibson SB. Methods for detectingautophagy and determining autophagy induced cell death.Can J Physiol Pharmacol 2010; 88:285-95.
  • 6Thoen LF, Guimars EL, Doll-L, et al. A role for autophagyduring hepatic stellate cell activation. J Hepatol 2011;55:1353-60.
  • 7Herndez-Gea V, Ghiassi-Nejad Z, Rozenfeld R, et al.Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in humantissues. Gastroenterology 2012; 142:938-46.
  • 8Lee YA, Wallace MC, Friedman SL. Pathobiology of liverfibrosis: a translational success story. Gut 2015; 64:830-41.
  • 9Chen Y, Choi SS, Michelotti GA, et al. Hedgehog controlshepatic stellate cell fate by regulating metabolism. Gastroenterology2012; 143:1319-29.
  • 10Hernandez-Gea V, Ghiassi-Nejad Z, Rozenfeld R, et al.Autophagy releases lipid that promotes fibrogenesis byactivated hepatic stellate cells in mice and in humantissues. Gastroenterology 2012; 142:938-46.

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