骨髓增殖性肿瘤的基因突变及治疗研究进展

Research progress of gene mutation and treatment of myeloproliferative neoplasms

骨髓增殖性肿瘤(MPNs)是一组起源于多能造血干细胞的恶性骨髓增殖性疾病,近年来我们对MPNs分子生物学的认识使得在疾病诊断及治疗等方面都取得了较大进步,本文将针对MPNs的基因突变及治疗方面的研究成果进行阐述。

Myeloproliferative neoplasms （MPNs） are clonal disorders of hematopoietic that are believed to arise from a transformed hematopoietic stem or progenitor cell and are manifested as progressive myeloid expansion of one or more differentiated myeloid lineages. In recent years, we had made big progress in diagnosis and treatment of this disease due to our understanding of molecular biology of MPNs. This article focused on the research of gene mutation and the treatment of MPNs.