酒精性周围神经病的治疗新进展及展望

New progress and future prospects for the treatment of alcoholic peripheral neuropathy

酒精性周围神经病是长期酒精摄入引起的周围神经轴索变性及脱髓鞘病变,主要表现为感觉异常、运动乏力、自主神经症状,其病程迁延,严重影响生活质量。目前临床多以戒酒、补充B族维生素、营养神经为治疗原则,疾病的治疗效果往往差强人意,症状不能得到明显改善。因此,必须寻找效果更佳的治疗药物。关于苯磷硫胺、α-硫辛酸等一系列药物对各种原因引起的周围神经病变的疗效,既往已有了深入的研究;本文将从这些药物的作用机制、临床应用角度来探讨它们是否有潜力成为酒精性周围神经病的治疗药物。

Alcoholic peripheral neuropathy is peripheral nerve axonal degeneration and demyelination caused by long-term alcohol intake, the main symptoms are paresthesia, limb weakness, autonomic symptoms, it is prolonged course and seriously affects the quality of life. The current clinical therapy principle is alcohol withdrawal, supplement of B vitamins, nutrition of nerve, the therapeutic effect of the disease is often unsatisfactory, the symptoms can not be significantly improved. Therefore, we must find better treatments. There has been a thorough study on efficacy of Benfotiamine,α-lipoic acid and a series of drugs on peripheral neuropathy by a variety of causes, the paper was explored whether they have the potential to cure alcohol peripheral neuropathy from the mechanism, the view of clinical application point of these drugs.