信号放大技术在电化学免疫传感器中的应用

Signal amplification strategies applied in electrochemical immunosensors

电化学免疫传感器是一种将电化学分析方法与免疫学技术相结合而发展起来的具有响应快速、灵敏度高、选择性好、操作简单、成本低等优点的生物传感器。近年来,基于新型纳米材料催化、酶催化以及生物学放大技术用于蛋白质检测的电化学免疫传感器的研究颇受关注。该研究综述简要介绍电化学免疫传感器的基本原理,重点评述了近年来基于各种信号放大技术在电化学免疫传感器中的应用进展。

Electrochemical immunosensors are valuable analytical tools as the advantages of rapid response, high sensitivity, good selectivity, simple manipulation and low cost, which combined the merits of electrochemical and immunoassay. Recently, amplified electrochemical biosensors have been received much attention, which achieved by employing nanomaterials, enzymes catalysis and biological amplification technique. The principle of electrochemical immunosensorsare presented, and the signal amplification strategies applied in electrochemical immunosensors are extensively reviewed.