我国家庭护理对糖尿病患者健康状况影响的Meta分析

Effect of homecare on health of diabetic patients in China:a Meta-analysis

目的评价我国家庭护理对糖尿病患者的影响。方法检索中国学术期刊数据库(CNKI)、万方科技期刊全文数据库(Wanfang data)、维普中文科技期刊数据库(VIP)和中国生物医学文献数据库(CBM)等,并按照事先定义的纳入和排除标准剔除不符合要求的文献,应用Meta分析方法比较实验组和对照组患者空腹血糖(fasting plasma glucose,FPG)、餐后2小时血糖(2-hour postprandial blood glucose,2h PG)、生活质量、治疗依从性的差异,以计算标准化均数差(standardized mean difference,SMD)及相对危险度(risk ratio,RR)为效应量进行合并分析。结果纳入12项随机对照研究,共1193例患者,其中实验组596例,对照组597例。结果显示,实验组患者FPG、2h PG、生活质量、治疗依从性均明显优于对照组,合并效应量及95%CI分别为SMD=-1.77,95%CI(-2.28,-1.26),SMD=-1.62,95%CI(-2.28,-0.95),SMD=1.31,95%CI(0.50,2.13),RR=1.27,95%CI(1.13,1.43),均P<0.01,差异具有统计学意义。结论家庭护理能够有效改善糖尿病患者的血糖,提高患者生活质量和治疗依从性,帮助患者建立健康的生活方式。

Objective To study the effect of homecare on the health of diabetic patients in China. Methods A retrieval was done all on CNKI, Wanfang database, VIP database, China Biological Medicine. After excluding the literature out of the criteria, the meta-analysis was performed to compare the intervention group and control one in terms of the fasting plasma glucose, 2-hour postprandial blood glucose, quality of life, treatment compliance, standardized mean difference（SMD） and risk ratio（RR）.Results 12 RCTs, which involved 1,193 participants including 596 patients in the intervention group and 597 patients in the control group, were included in the final analysis. The fasting plasma glucose, 2-hour postprandial blood glucose, the quality of life, treatment compliance of the intervention group were significantly better than those of the control group, with effect size and 95% CI ： SMD =-1.77, 95% CI（-2.28,-1.26）; SMD =-1.62, 95% CI（-2.28,-0.95）; SMD = 1.31, 95% CI（0.50, 2.13）; RR = 1.27, 95%CI（1.13, 1.43）（P〈0.01）. Conclusion Homecare can improve the plasma glucose and quality of life of patients with diabetes and can help them to develop a healthy lifestyle.