药学干预在促进喹诺酮类药物合理使用中的作用分析

Pharmaceutical Intervention in Promoting the Role of Quinolones Reasonable Use Analysis

目的探讨药学干预在促进喹诺酮类药物合理使用中的作用,并评估其效果。方法对该院喹诺酮类药物处方的合理性使用实施药学干预模式,并评估其干预前后的效果。结果医院的喹诺酮类药物的使用效果显著提高,药学干预后该院分离的革兰阴性菌如铜铝假单细胞菌、大肠埃希菌以及肺炎克雷伯菌对喹诺酮类药物的耐药性明显降低,差异具有统计学意义(P<0.05)。经药学干预后,该院喹诺酮类药物不合理使用处方量与干预前相比明显下降,差异具有统计学意义(P<0.05)。其中严重问题降低到0,重要问题和一般问题下降的趋势也比较明显,差异具有统计学意义(P<0.05)。药学干预后,该院喹诺酮类药物不合理用法以及用量与干预前相比明显的下降,差异具有统计学意义(P<0.05)。不合理联合用药的情况与干预前相比出现明显改善,差异具有统计学意义(P<0.05)。结论药学干预可以有效地促进喹诺酮类药物合理使用,降低药物的耐药性发生率,具有良好的效果。

Objective To investigate the effect of pharmaceutical intervention in promoting the rational use of quinolones,and evaluate its effect. Methods The implementation of pharmacy intervention rational use of quinolones prescriptions in our hospital, and to evaluate the effects before and after intervention. Results The medical use of quinolones effect significantly improved after intervention in our hospital pharmacy, such as drug resistance separation leather reduce copper Pseudomonas aeruginosa and Escherichia coli and Klebsiella pneumoniae to quinolones were Gram-negative bacteria the difference was statistically significant（P〈0.05）. The pharmaceutical intervention, unreasonable use of prescription and intervention of quinolones in our hospital than before significantly decreased the difference was statistically significant（P〈0.05）. The serious problem is reduced to 0, the important problem and the general problem of the trend is also more obvious the difference has statistical significance（P〈0.05）. Pharmaceutical intervention of quinolones in our hospital is reasonable usage and dosage compared with before intervention decreased significantly the difference was statistically significant（P〈0.05）. The situation of irrational combined use of drugs was significantly improved compared with that before intervention the difference was statistically significant（P〈0.05）. Conclusion pharmaceutical intervention can effectively promote the rational use of quinolones, reduce the incidence of drug resistance, has a good effect.