乙肝疫苗免疫后无应答者再次接种免疫效果的分析

No respondents again after hepatitis b vaccine immunization vaccination immune effect observation

目的总结性分析乙肝疫苗免疫后无应答者再次接种的免疫效果。方法选取该门诊2010年1月—2014年1月期间200例Hep B预防接种者作为研究对象,将41例免疫后无应答再次接种者分为观察组(21例)和对照组(20例),均按0、1、6个月方案接种,前者追加剂量,后者按照原剂量注射,比较两组再次接种免疫效果及副反应发生情况。结果再次接种Hep B1个月后测定抗-HBs,观察组抗-HBs阳转率(100.0%)高于对照组(80.0%),比较差异具有统计学意义(P<0.05);观察组再次接种副反应发生率(38.1%)高于对照组(30.0%),但比较差异无统计学意义(P>0.05)。结论初次全程免疫无应答者再次接种Hep B,可提高抗-HBs阳转率,注射剂量控制在60μg能够保证接种免疫的有效性和安全性。

Objective To summary respondents again after an analysis of the hepatitis b vaccine immunization vaccination immune effect. Methods To choose my clinic during January 2010 to January 2010, 200 cases of HepB vaccination as the research object, 41 patients after an immune response to vaccination is divided into the observation group （21 cases） and control group （20 cases）, all press 0, 1, 6 months plan vaccination, the former additional dose, the latter shall, in accordance with the original dose injection, compared two groups of vaccination immune effect and side effects happening again. Results After vaccination HepB1 months again determination of anti - HBs, anti - HBs Yang turn rate of observation group （100.0%） than the control group （80.0%）, more significant difference （P〈0.05）; Observation group again vaccination side effects （38.1%） than the control group （30.0%）, but the difference is not significant （P〉0.05）. Conclusion For the first time the entire immune HepB vaccination again no answer, can improve the anti - HBs Yang turn rate, dose control in 60 mug can ensure the effectiveness and safety of vaccination campaign.