联合肝实质离断及门静脉结扎的分期肝切除术研究进展

Research Progress of ALPPS

肝脏肿瘤是国际临床上面临的较为复杂的难题,治疗方法局限,联合肝脏离断和门静脉结扎分期肝切除术的出现是治疗肝脏肿瘤的较为先进的方法,它是目前出现的一种新颖的手术,肝脏肿瘤的治疗方法主要是切除带有肿瘤的肝脏,保护剩余的健康肝脏,联合肝脏离断和门静脉结扎的分期肝切除术在切除肿瘤肝脏后可以有效地促进剩余肝脏生长,使其体积增大。由于其方法并不完善,所以会引起较多的临床问题,例如:术后感染及并发症等,其治疗的疗效还需进一步的研究。该文首先介绍什么是联合肝脏离断和门静脉结扎分期切除术的形成、其次详细分析了其适应症、禁忌证及肝脏再生机制。最后介绍联合肝脏离断和门静脉结扎分期切除术的在未来的发展及面临的问题。

In the worldwide, the liver neoplasm is a relative complex disease and its treatment method is restricted. ALPPS（associating liver partion and portal vein ligation for stage hepatectomy） is an advanced therapy in the treatment of liver neoplasm. At present, the new therapy is to resect the liver with heoplasm and protect the healthy liver. After ALPPS, it can efficiently promote the growth of remaining liver in volume. However, the therapy is not perfect and has many clinical problems like postoperative infection and complications. Its clinical effect shall be further explored. In this paper, the defenition of ALPPS is introduced; then the indication, contraindication and regeneration mechanism is analyzed in detail;the future development and problems for ALPPS is finally conducted.