神经节苷脂治疗新生儿中重度缺血缺氧性脑病80例疗效分析

Effect Analysis of Ganglioside in Treatment of 80 Cases Neonatal Moderate and Severe Hypoxic-ischemic Encephalopathy

目的探讨神经节苷脂治疗新生儿中重度缺血缺氧性脑病的治疗效果。方法选取2008年1月—2015年8月于该院接受治疗的80例中、重度缺血缺氧性脑病患儿作为研究对象,随机将患儿分为对照组(n=40)和观察组(n=40)。对照组给予常规治疗,包括吸氧、保持正常血压、降颅压、控制惊厥等措施,观察组患儿在对照组治疗方式的基础上进行神经节苷脂静脉滴注。对比观察两组患儿的临床病症改善时间及治疗有效率情况。结果对照组患儿中,显效13例,有效18例,无效9例,治疗总有效率为77.5%,观察组患儿中显效20例,有效17例,无效3例,治疗总有效率为92.5%,差异有统计学意义(P<0.05)。与对照组相比,观察组患儿在肌张力恢复时间、原始反射恢复时间、意识状态恢复时间及惊厥消失时间方面均具有显著优势,差异有统计学意义(P<0.05)。结论神经节苷脂对于新生儿中重度缺血缺氧性脑病的治疗具有良好的疗效,且病程短,患儿无不良反应,值得在推广使用。

Objective To explore the clinical effect of ganglioside in treatment of neonatal severe hypoxic-ischemic encephalopathy. Methods From January 2008 to Augest 2015, 80 cases neonatal moderate and severe hypoxic-ischemic encephalopathy in our hospital were selected as the research objects, and were randomly divided into control group（n =40）and observation group（n =40）. The control group was given conventional treatment, including oxygen, maintaining normal blood pressure, lowering intracranial pressure, convulsions control and other measures, the observation group was treated by the ganglioside intravenous injection on the basis of the control, observing and comparing the improvement time of clinical symptoms and the treatment efficiency between the two groups. Results In the control group, 13 cases were markedly effective, 18 cases were effective, 9 cases were ineffective, the total effective rate was 77.5%, in the observation group, 20 cases were markedly effective, 17 cases were effective, 3 cases were ineffective, the total effective rate was 92.5%, the difference had statistical significance（P〈0.05）. Comparing with control, the muscle tension recovery time, primitive reflex recovery time, consciousness recovery time and convulsion disappearing time of the observation group had significant advantage, the difference had statistical significance（P〈0.05）. Conclusion Ganglioside in treatment of neonatal moderate and severe hypoxic-ischemic encephalopathy has a good clinical effect, and the course of disease is short, the patient has no adverse reaction, which is worthy of clinical application.