血塞通注射液和血栓通注射液致不良反应差异性比较

Comparison of Adverse Drug Reactions between Xuesaitong Injection and Xueshuantong Injection

目的比较血塞通注射液和血栓通注射液致药物不良反应(ADR)一般规律和特点的差异性,为临床合理选择药物提供参考。方法检索CBM、CNKI、VIP和万方数据库中从建库至2015年3月收录的血塞通注射剂和血栓通注射剂致ADR个案报告进行分类、归纳、统计、分析,对2种药物致ADR一般规律和特点的差异性进行统计学分析。结果共纳入血塞通注射液和血栓通注射液致ADR分别为156例和138例,二者在患者性别和年龄、溶媒种类和体积、ADR发生时间、联用药物数和类别等方面均无显著性差异(P>0.05)。相对于血栓通,血塞通致皮肤及其附件损害较高,而致呼吸系统损害和全身性损害则较小,差异性比较均有统计学意义(P<0.05)。血塞通致ADR以轻度为主,血栓通以中度为主。结论血塞通注射液和血栓通注射液致ADR的一般特点基本相似,累积器官/系统存在显著性差异,建议临床根据患者个体机能间的差异,有条件选择,以降低ADR发生。

Objective To compare the difference in regularity and characteristics of adverse drug reactions（ ADR） induced by Xuesaitong injection and Xueshuantong injection so as to provide reference for selection of clinical drugs. Methods Data were retrieved from CMB,CNKI,VIP and Wanfang database,related literature about ADR induced by Xuesaitong injection and Xueshuantong injection from the time of the establishment of the database to March of 2015. All ADR cases were classified and summarized. Statistical analysis was made of the regularity and characteristics of two types of drug-induced ADR. Results A total of 156 cases and 138 cases of ADR induced respectively by Xuesaitong injection and Xueshuantong injection were included. There was no statistical difference in gender and age of patients,solvent type and volume,onset time of ADR,or numbers and categories of combined drugs（ P〈0. 05）.However,compared to Xueshuantong injection,Xuesaitong injection caused serious damge to the skin and appendages（ P〈0. 05）. Conclusion The regularity and characteristics of ADR induced by Xuesaitong injection and Xueshuangtong injection are similar,but there are significant differences in the cumulative organ / system.