立体定向术联合化疗治疗原发性中枢神经系统淋巴瘤的效果分析

The effect of stereotactic surgery treatment with combination chemotherapy PCNSL were analyzed

目的探讨立体定向术（MIQ）联合化疗治疗PCNSL的效果分析。方法本次研究随机选取了2013年4月至2015年8月我院收治的50例明确病理后的PCNSL患者,随机分为数目相等的研究组和对照组,所有患者都采用立体定向术进行治疗,研究组加用大剂量甲氨蝶呤＋替莫唑胺胶囊以及化疗,最后比较两组患者的治疗效果。结果研究组患者在进行立体定向术后给予化疗,1~3周临床症状明显缓解,近期缓解率为100%,25例患者通过治疗后近期疗效完全缓解22例（88%）,部分缓解3例（12%）Karnofsky评分迅速由术前的50%上升为术后的80%,对照组完全缓解20例（80%）,部分缓解2例（8%）,近期缓解率为88%。研究组局控率以及生存率都明显高于对照组,肿瘤复发情况也较对照组好,数据差异具有统计学意义（P〈0.05）。结论立体定向术联合化疗治疗PCNSL具有一定的疗效以及安全性,有利于提高患者的生存率和改善预后降低复发率,立体定向术联合化疗也是临床治疗PCNSL的综合治疗方案之一,临床可进一步研究。

Objective to study the stereotactic surgery（MIQ）combined chemotherapy effect analysis of PCNSL.Methods this study randomly selected from the April 2013- August2015,our hospital after the 50 cases with clear pathological PCNSL patients,randomly divided into equal to the number of the group and the control group,all patients were treated by stereotactic surgery,the team used high-dose methotrexate for more thiazole amine capsule and chemotherapy,finally compare the therapeutic effect of two groups of patients.Results team in stereotactic surgery for chemotherapy patients,1-3weeks obviously alleviate clinical symptoms,the response rate was 100%,25 cases through the recent curative effect after treatment in patients with complete remission 22cases（88%）and partial in 3cases（12%）,Karnofsky score quickly by 50%50% of the postoperative preoperatively,control group complete remission 20cases（80%）,partial response in 2cases（8%）,the recent response rate of 88%.Group at the local control rate and survival rate were significantly higher than the control group,tumor recurrence is also better than control group,the data statistically significant difference（P〈0.05）.Conclusion the stereotactic surgery treatment with combination chemotherapy PCNSL has certain curative effect and security,to improve the survival rate and improve the prognosis of patients with lower recurrence rate,stereotactic surgery in combination with chemotherapy is one of comprehensive treatment in the clinical treatment of PCNSL clinical can be further study.