鸦胆子油乳联合尼莫斯汀治疗颅内恶性胶质瘤临床疗效观察

The study of brucea oil emulsion joint nimustine in the treatment of malignant gliomas

目的探讨鸦胆子油乳联合尼莫斯汀治疗恶性胶质瘤患者的临床疗效。方法选取我院112例胶质瘤患者,依据入院先后顺序分为实验组和对照组,每组56例。实验组应用鸦胆子油乳注射液联合尼莫斯汀,对照组单纯应用尼莫斯汀。两组均以1个月为一个化疗周期,均完成4个化疗周期以上,观察临床疗效、副作用和生存质量评分变化。结果两组临床疗效相比实验组总有效率为55.3%,对照组总有效率为25%,试验组优于对照组,差异有统计学意义(P<0.05);实验组生活质量改善率为71.4%,对照组为35.7%,实验组明显高于对照组,差异有统计学意义(P<0.05)。实验组中骨髓抑制率及肝功能损害低于对照组,两组相比P<0.05.结论鸦胆子油乳注射液联合尼莫斯汀治疗胶质瘤能提高疗效及改善胶质瘤患者的生活质量,降低副作用.

Objective To explore the clinical efficacy of Brucea oil emulsion joint nimustine in treatment the patients with malignant glioma.Methods Select 112 cases of glioma patients from my hospital,according to the order of admission into experimental and control groups,56 cases in each group.Experimental group used brucea oil emulsion injection and nimustine,control group oniy used nimustine.The two groups are one month for a chemotherapy cycle,they have completed four chemotherapy cycles.To observe the chage of clinical efficacy、toxicity and quality of life score.Results The two groups clinical efficacy copared,the total effective rate is 55.3%in the experimental group,in the control group is 25%,the test group better than the control group,the difference is statistically significant（P〈0.05）;Improve the quality of life in the experimental group is 71.4%,35.7%in the control group,the experimental group is significantly higher,the difference is statistically significant（P〈0.05）;Bone marrow suppression and liver dysfunction in experimental group are lower than control group,the two groups compared P〈0.05。Conclusion Javanica oil emulsion injection combined with nimustine can improve the efficacy of glioma and improve the quality of life in patients with glioma,reduce side effects.