盐酸多奈哌齐对中型脑外伤后认知障碍患者记忆功能及氧化应激功能的影响

Effects of donepezil hydrochloride on memory function and oxidative stress function of patients with cognitive dysfunction after moderate traumatic brain injury

目的探讨盐酸多奈哌齐对中型脑外伤后认知障碍患者记忆功能及氧化应激功能的影响。方法随机数字表格法将78例中型脑外伤后认知障碍患者分为两组各39例,对照组采取石杉碱甲片治疗,观察组则给予盐酸多奈哌齐治疗,均干预12周,比较两组治疗前后MMSE评分、WMS评分、ADL评分及氧化应激功能指标。结果观察组治疗后MMSE评分、WMS量表总分、ADL评分分别为(21.27±3.69)分、(83.08±20.27)分、(20.12±8.36)分,较对照组的(18.97±2.86)分、(73.87±20.20)分、(27.26±10.44)分差异有统计学意义(P<0.05)。观察组治疗后SOD、CAT、GSH水平明显高于对照组,差异有统计学意义(P<0.05)。结论盐酸多奈哌齐能明显改善中型脑外伤后认知障碍症状,显著提高患者记忆功能及血清抗氧化能力。

Objective To investigate the effects of donepezil hydrochloride on memory function and oxidative stress function of patients with cognitive dysfunction after moderate traumatic brain injury.Methods 78 cases of patients with cognitive dysfunction after moderate traumatic brain injury were divided into two groups by random number table method,with 39 cases in each group.The control group were treated by huperzine A tablets while the observation group were treated by donepezil hydrochloride.The two group were intervened for 12 weeks.The MMSE scores,WMS scores,ADL scores and oxidative stress function indexes were compared between the two groups before and after treatment.Results The MMSE score,WMS total score and ADL score in the observation group after treatment were（21.27±3.69）,（83.08±20.27）,（20.12±8.36）respectively.Compared with those in the control group[（18.97±2.86）,（73.87±20.20）,（27.26±10.44）],the differences were statistically significant（P〈0.05）.The levels of SOD,CAT and GSH in the observation group after treatment were significantly higher than those in the control group（P〈0.05）.Conclusion Donepezil hydrochloride can significantly improve the symptoms of cognitive dysfunction after traumatic brain injury and significantly improve memory function and serum antioxidant capacity of patients.