甲泼尼龙联合阿奇霉素治疗小儿支原体肺炎的临床疗效

Clinical Curative Effect of Methylprednisolone Combined with Azithromycin in Treatment of Mycoplasma Pneumonia in Children

目的研究讨论甲泼尼龙联合阿奇霉素对小儿支原体患儿的安全性与临床疗效。方法在2013年10月—2015年2月来该院治疗小儿支原体的患者中随机抽取90例,将其按随机数字表法分为观察组和对照组各45例。给于对照组患儿静脉滴注药物阿奇霉素,按10 mg/kg,共治疗7 d;在对照组的基础上给予观察组患儿静脉滴注药物甲泼尼龙,按2mg/kg,待患儿体温恢复到正常时改为口服药物甲泼尼龙片,按1 mg/kg,共治疗5 d。观察比较两组患儿不良反应的发生状况、临床疗效、住院时间、退热时间和咳嗽的消失时间。结果研究结果表明,观察组患儿的总有效率(93.33%)显著高于对照组(82.22%);观察组患儿的住院时间、退热时间、咳嗽的消失时间均显著短于对照组患儿,其差异具有统计学意义(P<0.05)。观察组与对照组分别有6例(13.33%)和7例(15.55%)患儿出现恶心、呕吐等不良反应,两组患儿在不良反应方面比较,差异无统计学意义(P>0.05)。结论甲泼尼龙联合阿奇霉素可以有效治疗小儿支原体肺炎,该两种药物合用可有效控制患儿病情,快速缓解其临床体征,且安全性高,值得临床广泛应用。

Objective To research and discuss the security and clinical curative effect of methylprednisolone combined with azithromycin in treatment of mycoplasma pneumonia in children. Methods 90 cases of patients with mycoplasma pneumonia in children treated in our hospital from October 2013 to February 2015 were extracted and randomly divided into two groups with 45 cases in each, the control group were treated with intravenous infusion of azithromycin（10mg/kg） for 7 days,the observation group were treated with intravenous infusion of methylprednisolone（ 2mg/kg） on the basis of the control group, and it was instead of oral administration of methylprednisolone tablets（1mg/kg） for 5 days when the children＇s body temperature returned to normal, the occurrence of adverse reactions, clinical curative effect, length of stay, fever reducing time and cough disappearance time of the two groups were observed. Results The research results showed that the total effective rate in the research group was obviously higher than that in the control group,（93.33% vs 82.22%）, the length of stay, fever reducing time and cough disappearance time in the observation group were obviously higher than those in the control group, and the differences were statistically significant（P〈0.05）, the adverse reactions such as nausea and vomiting occurred to 6 cases（13.33%）in the observation group and 7 cases（15.55%）in the control group, and there was no obvious difference in the adverse reaction between the two groups without statistical significance,（P〉0.05）. Conclusion Methylprednisolone combined with azithromycin can effectively treat mycoplasma pneumonia in children, the combined use can effectively control the children＇s disease condition, relieve their clinical signs quickly with high security, which is worth wide application in clinic.