Cu^+/脯氨酸锂催化微波辅助合成苯并咪唑并喹喔啉衍生物的研究

Copper/Proline Lithiumas Catalyzed Microwave-Assisted Synthesis of Benzo[4,5]Imidazo[l,2-α]Quinoxalines Derivatives

目的用微波辐射催化法合成苯并咪唑并喹喔啉衍生物。方法在120 W微波辐射条件下,以碘化亚铜和脯氨酸锂为催化剂,N-对甲苯磺酰基-2-碘苯胺和2-氯甲基苯并咪唑在110℃二甲基甲酰胺中反应30min得到苯并咪唑并喹喔啉及其衍生物。结果发现一种合成苯并咪唑并喹喔啉衍生物的新方法,获得7个相应的苯并咪唑并喹喔啉化合物,均已通过1 H NMR、13 C NMR和质谱确认结构,最高收率为94%。结论微波辐射法Cu+/脯氨酸锂催化合成吡咯[1,2-α]喹喔啉,与传统方法比较,具有时间短、收率高的优点。

Objective To synthesize Benzo[4,5]imidazo[l,2-α]quinoxalines derivatives under microwave irradiation in DMF. Methods A variety of N-（2-iodophenyl）-4-methylbenenesulfona-mides and2-（chloromethyl）-1H-benzo[d]imidazoles could be reacted to give the desired corresponding products in high yields in 110 ℃ DMF for 30 min using copper/proline lithiumas catalysts under microwave irradiation. Results We have developed an efficient protocol for synthesizing benzo[4,5]imidazo[l,2-α]quinoxalines;7target compounds could be synthesized in good to excellent yields up to 94%,and all of them were further characterized by ^1 H NMR,^13 C NMR and MS analysis. Conclusion Synthesis of target benzo[4,5]imidazo[l,2-α]quinoxalines compounds under microwave irradiation in water has an advantage of short reaction time and higher yields compared to the conventional method.