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二甲双胍对血清素水平的影响及与其所致腹泻的关系 被引量:5

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摘要 二甲双胍是2型糖尿病患者的一线用药,但近30%患者服用后出现胃肠道反应(腹泻、恶心、呕吐等),是限制该药在糖尿病患者中使用的最主要障碍。二甲双胍致胃肠道不良反应可能机制包括刺激肠道分泌血清素(serotonin)又称5羟色胺(5-HT),分泌胰高糖素样肽,导致胆汁盐吸收不良,影响肠道对葡萄糖的吸收等[1]。
出处 《贵州医药》 CAS 2015年第12期1080-1082,共3页 Guizhou Medical Journal
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