手性方酰胺催化巴比妥酸和硝基烯的不对称Michael加成反应

Organocatalytic Asymmetric Michael Addition of Barbituric Acid to β-Nitroalkenes

用手性环己二胺衍生的方酰胺催化1,3-二甲基巴比妥酸和硝基烯的不对称Michael加成反应,合成了一系列新型巴比妥衍生物,其结构经1H NMR和13C NMR表征。并考察了底物结构对反应收率和立体选择性的影响。结果表明：该反应可获得较高的收率（80%-100%）和中等至良好的对映选择性（ee 43%-90%）。

Organocatalytic asymmetric Michael addition of 1,3-dimethylbarbituric acid to/3-nitroalkenes was studied using chiral squaric-amide as the catalyst. The influence of substrate structure on the enantioselectivity of the reaction was investigated. The addition products were obtained in high yields （80% - 100% ） and moderate to good enantioselectivity （ee 43% - 90% ）. The structures were characterized by ^1H NMR and ^13C NMR.