注射用乌司他丁联合参麦注射液治疗急性胰腺炎57例临床研究

Ulinastatin Combined with Shenmai Injection for Treating Acute Pancreatitis in 57 Cases

目的观察乌司他丁联合参麦注射液治疗急性胰腺炎的疗效,并观察血尿淀粉酶、血常规和生化各指标的改善效果。方法选取2014年6月至2015年6月就诊的150例急性胰腺炎患者,根据随机数字表法和患者意愿,分成对照组和治疗组,各75例。对照组给予乌司他丁(20 U/d、每日1次共5 d→10 U/d、每日1次共5 d)治疗,治疗组给予乌司他丁联合参麦注射液(50 m L/d、每日1次共10 d)治疗。连续用药10 d后,对两组血尿淀粉酶、血常规和生化各指标的改善情况进行检测分析与比较。结果治疗前,两组患者的血尿淀粉酶、血常规和生化各指标差异无统计学意义(P>0.05),治疗后,均比治疗前有明显降低(P<0.05),治疗组显著低于对照组(P<0.05)。对照组的治疗总有效率为85.33%,治疗组为93.33%,差异具有统计学意义(P<0.05)。治疗组患者的不良反应发生率为9.33%,对照组为8.00%,差异无统计学意义(P>0.05)。结论乌司他丁联合参麦注射液治疗急性胰腺炎,可明显降低患者的血尿淀粉酶、血常规和生化各指标,临床疗效好,值得推广。

Objective To explore the efficacy of ulinastatin combined with Shenmai Injection in treating acute pancreatitis, and to observe the improvement of urine amylase, blood routine and biochemical indexes. Methods 150 patients from June 2014 to June 2015 were selected and divided into the control group and the treatment group according to the sequence of patient records and the wishes of the patients, 75 cases in each group. The control group received ulinastatin treatment（ 20 U/d, once daily for 5 d; 10 U/d, once daily for 5 d）,the treatment group received ulinastatin combined with Shenmai Injection treatment（ 50 m L/d, once daily for 10 d）. After continuous medication for 10 d, the improvement of urine amylase, blood and biochemical indexes case were detected, analyzed and compared.Results Before treatment, the urine amylase, blood biochemical indexes of the two groups showed no statistically significant difference（ P〈0. 05）; after treatment, the indexes in both groups significantly decreased（ P〈0. 05）, and the treatment group was significantly lower than the control group（ P〈0. 05）. The total effective rate in the control group was 85. 33%, which was significantly lower than 93. 33% of the treatment group（ P〈0. 05）. The incidence rate of adverse reaction in the treatment group was 9. 33%, which had no statistically significant difference with 8. 00% in the control group（ P〈0. 05）. Conclusion Ulinastatin combined with Shenmai Injection in treating acute pancreatitiscan significantly reduce the patient＇s urine amylase, blood and biochemical indexes, has better clinical efficacy, which is worthy of clinical promotion.