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1例双瓣置换术后血小板减少患者华法林合理用药分析 被引量:2

Analysis of Clinical Pharmacists Participating in the Warfarin Anticoagulation Treatment for 1 Double Valve Replacement Patient with Thrombocytopenia
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摘要 目的探讨双瓣置换术后并发血小板减少的患者的抗凝治疗策略,为临床药师参与抗凝治疗提供参考。方法临床药师回顾性分析1例双瓣置换术后患者血小板减少的原因,结合药代动力学知识和相关文献资料,确定华法林初始剂量和目标国际标准化比值(INR),优化抗凝方案。结果患者血小板计数逐渐恢复正常;华法林抗凝治疗以5 mg为初始剂量,目标INR为1.8~2.5。经过五次剂量调整后以3.125 mg的维持剂量带药出院,出院时INR为1.5。结论临床药师参与可为患者提供更加安全、有效的治疗方案。 Objective To explore the anticoagulation strategies for 1 double value replacement patient with thrombocytopenia, and to nsummarize the experience of clinical pharmacists participating in the anticoagulant therapy. Methods The clinical pharmacist retrospec-tively analyzed 1 patient with thrombocytopenia after double valve replacement. According to pharmacokinetic knowledge and related lit-eratures, the initial dose of warfarin and the target international normalize( INR) were determined and the anticoagulation regimen was optimized. Results The platelet counts gradually returned to normal; the warfarin anticoagulation was started with an initial dose of 5 mg,the target INR was 1. 8- 2. 5. After adjusting the dosage five times, the patient discharged with a maintenance dose of 3. 125 mg and an INR of 1. 5. Conclusion The participation of clinical pharmacists can provide more safe and effective treatment regimen for patients.
出处 《中国药业》 CAS 2016年第5期59-62,共4页 China Pharmaceuticals
关键词 瓣膜置换 血小板减少 华法林 国际标准化比值 valve replacement thrombocytopenia warfarin international standardization ratio
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参考文献11

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