摘要
非对称性二甲基精氨酸(ADMA)通过竞争性抑制内源性一氧化氮合酶而减少一氧化氮生成及内皮祖细胞数量,引起血管内皮功能不全,导致动脉粥样硬化、冠心病、高血压、高脂血症、肺动脉高压等心血管疾病的发生发展。本文对ADMA导致心血管疾病的机制、ADMA与心血管疾病的关系及ADMA的代谢途径进行综述,旨在为心血管疾病的治疗提供参考。
Asymmetric dimethylarginine can reduce the generation of nitric oxide and endothelial progenitor cells by competitive inhibiting endogenous nitric oxide synthase, lead to vascular endothelial dysfunction, result in occurrence and development of atherosclerosis,coronary heart disease,hypertension,hyperlipidaemia,pulmonary hypertension and so on. This paper reviewed the mechanism of asymmetric dimethylarginine- induced cardiovascular disease,correlation between asymmetric dimethylarginine and cardiovascular disease,and metabolic pathways of asymmetric dimethylarginine,to provide references for the treatment of cardiovascular disease.
出处
《实用心脑肺血管病杂志》
2016年第3期1-3,共3页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
