569例药品不良反应报告的相关因素分析

Analysis on Clinical Relative Factors of 569 Cases of Adverse Drug Reactions

目的:分析我院药品不良反应(ADR)发生的原因与特点,为临床合理用药提供依据。方法:对我院2012年12月15日至2013年12月15日上报的569例ADR报告,采取回顾性分析,采用Microsoft office Excel表格,对患者性别、年龄、ADR分级、给药途径、药品类别、累及器官和(或)系统及临床表现、各器官系统涉及的药品、因果关系评价、转归等因素进行分析。结果:静脉给药方式ADR发生率最高(52.90%);心血管系统药物引起的ADR居首(29.17%),其次为抗肿瘤药(23.90%),第3位为抗微生物药(11.42%);临床表现以消化系统损害最常见(40.77%);绝大多数发生ADR的患者能痊愈(40.07%)和好转(51.32%)。结论:应加强ADR的监测和报告,以促进临床合理用药、确保患者用药安全。

Objective： To analyze the causes and features of adverse drug reactions（ ADR） in our hospital. Methods： 569 ADR case reports collected from December 15,2012 to December15,2013 in our hospital were analyzed statistically in respect of gender,age, ADR level, route of administration, category of the drugs, systems involved, clinical manifestation, causality,results. Results： The ADR incidence rate caused via intravenous dip（ 52. 90 %） was highest. The ADR incidence rate（ 29. 17 %）caused mainly by cardiovascular drugs. The ADRs were chiefly characterized by gastrointestinal lesions（ 40. 77 %）. Most of ADR patients can be cured（ 40. 07 %） or improved（ 51. 32 %）. Conclusion： ADR monitoring and reporting should be strengthened to promote the rational use of drugs of the clinical.