不同抗菌药物治疗癫痫患者院内细菌性感染的研究

A Study of Different Antimicrobial Drugs for Treatment of Nosocomial Bacterial Infections in Patients with Epilepsy

目的:探讨不同抗菌药物治疗癫痫患者院内细菌性感染的临床效果。方法:多中心分析癫痫患者院内细菌性感染患者221例,根据治疗药物的不同将其分为A组108例和B组113例,A组给予阿奇霉素治疗,B组给予头孢噻肟治疗,统计2组疗效及治疗时间。结果:A组的痊愈、显效、进步以及总有效率分别为68.52%、26.85%、4.63%和95.37%,B组分别为33.63%、42.78%、23.89%和76.11%。A组的痊愈率和总有效率均明显高于B组,差异有统计学意义(P<0.05)。A组的体温恢复时间、其他症状消失时间、其他体征消失时间以及白细胞计数正常时间均明显短于B组,有显著性差异(P<0.01)。结论:与头孢噻肟相比,阿奇霉素用于治疗癫痫患者院内细菌性感染,疗效更好,且治疗时间缩短。

Objective：To study the efficacy of different antimicrobial drugs for nosocomial bacterial infections treatment in patients with epilepsy. Methods： Two hundred and twenty-one epilepsy patientswith nosocomial bacterial infectionsin multicenter were enrolledand divided into two groups according to different drugs.Group A（n =108） was administered azithromycin andgroup B（n = 113） was administered cefotaxime oxime. The efficacy and treatment time were compared separately between the two groups. Results： In the group A, the rate of being cured,markedlyeffective,progressed and the total effectiveness was68.52%, 26.85%, 4.63% and 95.37%,respectively, and33.63%, 42.78%, 23.89% and 76.11%, respectively In the group B. The Cured rate and total effectiveness rate in the group A were significantly higher than those in the group B（P〈0.05）. The body temperature recover time, symptoms disappeared time, signs disappeared time and white blood cell counts recover time were significantly shorter in the group A than thosein the group B（P〈0.01）. Conclusion： Compared to cefotaxime, the efficacy of azithromycin for nosocomial bacterial infections treatment inepileptic patients was better, and the treatment time was shorter.