期刊文献+

盐酸地尔硫卓合成工艺改进

Improved Synthesis of the Diltiazem Hydrochloride
下载PDF
导出
摘要 报道了苯并硫氮卓类钙拮抗剂盐酸地尔硫卓的一种新合成方法,并对工艺进行了优化,该方法操作简便、收率较高、降低成本且适合工业化生产。 A new method was reported for synthesis of the diltiazem hydrochloride. Being well optimized,the improved process has the merits of simple operation, high yield and low cost to meet the needs of manufacturing process.
出处 《浙江化工》 CAS 2016年第3期18-19,29,共3页 Zhejiang Chemical Industry
关键词 盐酸地尔硫卓 新合成方法 工艺优化 降低成本 diltiazem hydrochloride new method process optimization low cost
  • 相关文献

参考文献8

  • 1王力心,王一兵.钙拮抗剂对心血管系统的作用及临床应用[J].黑龙江医学,2002,26(8):579-580. 被引量:7
  • 2Simonovitch H,Hoffmann T,Sassoon S.Benzothiazepinone derivatives:EP,1580303[P].2005-09-28.
  • 3Nagao S,Kurabagashi K,Eutamura N,et al.1,5-Benzoderivatives:US,4416829[P].1983-11-22.
  • 4Kugita H,Inoue H,Ikezaki M.Pharmacologically effective5-(aninoalkyl)-2-phenyl-1,5-benzothiazepin-4(5H)-ones:Ger.Offen.,1805714[P].1969-06-19.
  • 5Kugita H,Inoue H,Ivezaki M.Synthesis of 1,5-benzothiazepine derivatives[J].Chem Pharm Bull,1971,19(3):595-602.
  • 6Manghisi E,Perego B.A Process of the preparation of diltiazem:WO,9210485[P].1992-06-25.
  • 7Hytoenen M.Method of the preparation of benozthiazepinone derivative as an intermediate of diltiazem:EP,702009A1[P].1996-03-20.
  • 8Hytoenen M.Process of manufacture of diltiazem:EP,0728751A2[P].1996-08-28.

二级参考文献3

  • 1Ielis.Annual Review of Medieine[J].1985,43:365.
  • 2Freedman SB.American Journal of Cardiology[J].1990,51:712.
  • 3江明性,杨藻宸.药理学[M].第4版.北京:人民卫生出版社,1999.140:194.

共引文献6

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部