摘要
对头孢妥仑酯的重要中间体头孢妥仑钠在甲醇溶液中不同条件下的稳定性进行考察.利用高效液相色谱监控头孢妥仑钠在甲醇溶液中不同条件下降解杂质含量的变化、合成及分离纯化获得杂质单体,并用HRMS、1H-NMR对所分离的杂质进行结构解析,为制备头孢妥仑酯选择合适的溶剂提供参考.
The paper studies the stability of cefditoren sodium which is an important intermediate of cefditoren pivoxil in methanol solution under different conditions. HPLC is used to monitor the change of impurity content of cefditoren sodium in methanol under different conditions. Synthesis,separation and purification are used to obtain the impurity. Then,the impurity is structurally analyzed by HRMS and1H-NMR. All provide references for selecting a suitable solvent for the preparation of cefditoren pivoxil.
出处
《成都大学学报（自然科学版）》
2016年第1期1-4,共4页
Journal of Chengdu University（Natural Science Edition）
基金
国家科技重大专项--重大新药创制(2012ZX09202101-013)资助项目
