针刺联合五行音乐治疗肝气郁结型抑郁症疗效及安全性评价

Efficacy and Evaluation to Acupuncture combined with Five Elements Music Therapy for Depression of Liver-qi Stagnation

目的:观察针刺联合五行音乐治疗肝气郁结型抑郁症的有效性及安全性。方法:遵循随机对照试验原则,将80例患者按就诊顺序随机分为治疗组40例和对照组40例,两组基础治疗均以针刺联合五行音乐,针刺以疏肝理气为治疗原则,选穴膻中、内关、神门、印堂、百会、四神聪、太冲、三阴交;五行音乐选取《中国传统五行音乐》之角调式,每日1次,周末不进行治疗。对照组除上述疗法外嘱患者口服米氮平,每天30 mg,两组均于治疗前、治疗8周末采用HAMD抑郁量表为主要疗效评价指标;采用中医郁证证候量表进行中医证候疗效评定为次要指标;采用改良的不良反应量表(TESS)进行安全性评价。结果:治疗8周末,治疗组、对照组治愈率分别为82.50%、80.00%,组间疗效相当(均P>0.05),两组HAMD评分与治疗前比较均明显降低(P<0.05);而治疗组在改善中医证候评分、减少TESS不良反应评分方面优于对照组(P<0.05)。结论:针灸联合五行音乐治疗抑郁症的疗效是肯定,且具有较高安全性。

Objective：To observe the efficacy and safety of depression of liver stagnation treated with acupuncture combined with five elements music therapy. Methods：According to the principle of randomized controlled trials,80 case were randomly divided into treatment group with 40 cases and control group with 40 patients. Both groups were treated with acupuncture and five elements music therapy. The acupuncture follows the principle of soothing the liver and rectifying qi,and the points applied were Danzhong,Neiguan,Shenmen,Yintang,Baihui,Sishencong,Taichong,and Sanyinjiao. The five element music is the Jiao mode of the music from Traditional Chinese Five Elements Music,once per day,except the weekend. In the control group,besides the above- mentioned therapy,patients were given mirtazapine orally,30 mg a day,both groups were evaluated with HAMD depression scale before the treatment and in the 8th week of treatment,which is the major evaluation index. The traditional Chinese medicine（TCM） efficacy was evaluated with TCM depression syndrome scale,which is the secondary evaluation index. Modified TESS scale was applied to evaluate the safety. Results：The cure rates of the treatment group and the control group were 82.50% and 80.00%,respectively,without difference（P〉0.05）. HAMD scores became lower in both groups than before treatment（P〈0.05）;improvement of TCM syndrome score and reduction of TESS score in experiment were better than the control group. Conclusion：Depression treated with acupuncture and five elements music therapy is of positive effect,and is of high safety.