连续护理措施对胃癌患者术后围化疗期不良反应及免疫功能的影响

Efficacy of continuous nursing on adverse reactions and immune function of postoperative patients with gastric cancer

目的探讨连续护理措施对胃癌术后围化疗期不良反应及免疫功能的影响。方法选取2010年1月至2013年1月间收治的120例术后进行化疗的胃癌患者,按照随机数字表法分成观察组和对照组,每组各60例。观察组患者采用连续护理进行干预,对照组患者采用常规护理模式进行围化疗期护理。比较两组患者围化疗期不良反应发生情况以及免疫功能的变化。结果第1个和第3个疗程结束后,观察组患者白细胞下降、恶心呕吐、肌肉关节痛、外周神经感觉异常和脱发发生率均显著低于对照组,差异均有统计学意义(均P<0.05);同化疗前相比,观察组患者化疗之后CD3+、CD4+淋巴细胞亚群数量和CD4+/CD8+均明显增高(P<0.01),同时观察组患者化疗之后CD3+、CD4+淋巴细胞亚群数量和CD4+/CD8+高于对照组,差异均有统计学意义(均P<0.01)。结论连续护理可以改善胃癌患者术后恶心、脱发以及关节疼痛等临床症状,且有助于免疫功能的恢复,值得临床推广。

Objective To explore the efficacy of continuous nursing on adverse reactions and immune function of postoperative patients with gastric cancer. Methods From January 2010 to January 2013 in Dazu District People’s Hospital of Chongqing City,120 cases of gastric cancer underwent surgery and chemotherapy were selected and randomly divided into the observation group and the control group,with 60 cases in each group. Patients in the observation group received continuous nursing care. Patients in the control group received conventional care. Changes of reaction conditions and immune function during chemotherapy were observed. Results After first courses of treatment and third courses of treatment,leukopenia,nausea,vomiting,muscle and joint pain,peripheral nerve paresthesia,degree of hair loss in observation group were significantly lower than those of the control group,and the difference was statistically significant（ P 〈 0. 05）. Compared with before chemotherapy,after chemotherapy,CD3＋,CD4＋lymphocyte subsets and CD4＋/ CD8＋were significantly higher in the observation group（ P 〈 0. 01）. After chemotherapy,CD3＋,CD4＋lymphocyte subsets and CD4＋/ CD8＋of the observation group were higher than those of the control group,and the difference was statistically significant（ P 〈 0. 01）. Conclusion Continuous care can improve the clinical symptoms of patients with gastric cancer postoperative nausea,hair loss and joint pain,and help restore immune function,worthy of promotion.