左氧氟沙星联合阿奇霉素治疗宫颈炎

Clinical efficacy observation of levofloxacin combined with azithromycin on cervicitis

目的：探讨左氧氟沙星联合阿奇霉素用药治疗关节炎的临床疗效及安全性。方法选取2012年7月至2014年7月在确山县人民医院接受宫颈炎治疗的78例女性患者作为研究对象，随机双盲法分为实验组和对照组，对照组给予常规阿奇霉素治疗，实验组在此基础上加用左氧氟沙星，观察两组临床疗效及1年期复发情况。结果实验组痊愈21例，总有效率为95．0%；对照组痊愈15例，总有效率为81．6%。实验组痊愈率、有效率均显著高于对照组，差异有统计学意义（P〈0．05）。实验组用药后出现不良反应5例，不良反应发生率为12．5%，与对照组的15．8%比较差异未见统计学意义（P〉0．05）。随访1年实验组宫颈炎复发率为5．0%，显著低于对照组的18．4%，差异有统计学意义（P〈0．05）。结论左氧氟沙星联合阿奇霉素治疗宫颈炎疗效显著，能有效减少不良反应发生率，安全可靠，是治疗宫颈炎等疾病的理想用药思路。

Objective To investigate the clinical efficacy and safety of levofloxacin combined with azithromycin on arthritis. Methods Seventy-eight cases of cervicitis female patients in the people’ s of hospital Queshan treated from July 2012 to July 2014 were selected as research subjects, and divided them into experiment group and control group according to randomized double-blind. The control group received conventional treatment with azithromycin, and the experiment group was given levofloxacin in addition, the clinical effects and 1-year recurrences were observed. Results Twenty-one cases were cured in experiment group, the total efficiency was 95. 0%; and 15 cases were cured in the control group, the total efficiency was81. 6%. The cure rate and effective rate in experiment group was signifi-cantly higher than that of the control group （ P〈0. 05 ） . Five cases of adverse reactions occurred in the experiment group after treatment, the incidence of adverse reactions was 12. 5%, which had no signifi-cant difference in comparison to that of the control group （15. 8%, P〉0. 05）. After 1-year follow-up, the cervicitis recurrence rate of the experiment group was 5. 0%, which was significantly lower than that in the control group over the same period （ 18. 4%, P〈0. 05 ） . Conclusions Levofloxacin combined with azithromycin cervicitis has significant effect and can effectively reduce the incidence of adverse reac-tions, safe and reliable, the ideal drug treatment ideas cervicitis and other diseases.