抗海洛因成瘾疫苗的研究进展

Research Progress in Vaccines against Heroin Addiction

海洛因是我国流行最广的毒品,危害严重,复吸率极高。现有的抗海洛因成瘾疗法存在很多局限。毒品疫苗诱导机体产生针对毒品的特异性抗体,阻断毒品进入中枢发挥作用,在预防复吸,治疗成瘾方面显示了卓越的前景。本文就近年来抗海洛因成瘾疫苗的研究进展作一综述,针对疫苗的作用机制与疫苗的构建方式,分析了海洛因疫苗的研究现状和未来面临的挑战。

Heroin is the most abused drug in China with seriously damaging social consequences. The currently available therapies to treat heroin addiction continue to have many limitations. A vaccine capable of blocking heroin＇s effects can provide a long-lasting and sustainable adjunct to heroin addiction therapy. We review the status of research and development of heroin vaccines and outline the challenges associated with the development of anti-addiction vaccines and their use as future therapeutics.